Layumon22s
+1y
you'll go through brakes a little bit quicker because you'll have more rotational inertia further away from the center, and you'll lose some acceleration, even if they do weigh the same because chromed metal weighs more than rubber so you have more mass at a further distance, it's therefore harder to stop/get going. I recommend upgrading to an ultra high performance brake pad and cross-drilled and/or slotted rotors to help with the braking, check out ebay for rotors at a good price. Or just go ahead and put a big brake kit, but that'll cost you more than the rims and tires.
you'll also notice a slight decrease in ride comfort because you'll have less tire between you and the road, which means less dampening force for bumps and potholes.
i've had 22s on my f150 for over 25k, and knock on wood, never had any tranny or rear end problems.