if your looking for a simple answer, i don't think i can give it to you. typically i run through the gear train calculations to see what rpms i would be running at what speed and what gear. less rpms = less load on engine = possibly better gas mileage.
check out rangerstation.com, this should give you some sort of an idea
http://therangerstation.com/tech_library/gearandtirechart.html