scotch
+1y
When you get it hot, you're going to get pre-ignition and/or detonation - evidenced by knocking and pinging. Keep it cool and you won't have that problem unless you have some other issues.
The thread title says "random misfire" but you describe it as "every other cylinder cycle."
Congratulations on 400K miles on the truck. With that many miles, your lighting and washer pump issues are most likely caused by a dirty and possibly worn out combination switch - the housing on the column that holds all of the other switches (parking light, head light, turn signal, hazard, wiper, & washer pump.)
They are usually just dirty and can be cleaned up. ABE has great thread on taking it apart and cleaning the individual switches here:
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On the wiper side of the switch, I detailed the wiper/pump switch starting on post #15 of this thread:
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If your wiper fuse is good (or the wipers work), then I would pull the combo switch and give the individual switches a good cleaning. This is a very common problem - although usually more common on the light switches than the wipers.