Cusser
+1y
Four full turns on the mixture screw is a lot. So my guess is that you are sucking in air somewhere, a vacuum leak, common with Weber installation. Did you remove the Weber or its adapters recently? I had a vacuum leak on mine, even with Permatex Aviation on the gaskets (re-used gaskets). Since I was too impatient to order new gaskets (now I have some extras), I took Dan Woodland's advice and cut new ones from rubberized gasket material (used Permatex on those too).
Now - in hindsight or new learnings - I know that I should've checked/sanded the adapter plates absolutely flat using wet/dry on a sheet of glass, to eliminate vacuum leaks. The sealing surfaces on these are really small, so everything has to be just flat.
Also check all your vacuum caps, they can crack and/or break off. Better quality ones or use a piece of vacuum hose and a wooden golf tee, or rute two nipples together.