Three years ago I installed 6.5 inch speakers in the similar 1998 Frontier regular cab my daughter drives, just had to cut off a plastic nub in the mounting ring (or could've drilled a corresponding hole in the speaker frame) and had to solder the new speaker terminals because the Frontier ones used a proprietary connector.
I needed to replace the door speakers in my recently-acquired 2004 Frontier King Cab. Internet searching and posting on two Frontier forums for a few weeks led me to find that nobody actually KNEW what size speakers they would take, even sites like Crutchfield. So, knowing that the 1998 used 6.5 inch speakers, I bought a set off those and also bought a pair of 5.25 inch speakers, since that truck is 100 miles away.
Anyway, after taking the door panels off, found out that Nissan apparently thought too many were taking away their replacement speaker business and had changed to a one-piece speaker/mount using three mounting screws, used a speaker with the positive and negatives opposite to every other speaker I have ever seen, and still used a proprietary connector.
Anyway, the 6.5 inch speakers would fit and not hit the window when down (Dual DS Series #DS652) if I drilled four holes four mounting with sheet-metal screws supplied with the speakers. I also stripped the speaker wires a little (without cutting) and spliced in the wires supplied. Then I pushed the wire harness to the inside part of the door, and connected everything up.
Thanks a bunch, Nissan !!! When I had joked on the Frontier board that by buying both 6.5 and 5.25 inch speaker sets in advance, I was assuring that Nissan would have some "specialty" ones, and someone said that Toyota does similar.