91_2600i
+1y
Loud Vibration? Loud noise? Strong Vibration? All of the above?
Does it seem to come from the front more than the rear? Or vice versa?
Could be any number of things. Is it completely smooth prior to 5th? I would leave it in 4th and take up to the same speed you hear/feel vibration in 5th gear, just to make sure it's not happening at that speed that you hit in 5th gear instead of 5th gear itself. If you can hit the same speed in 4th (60 mph? 70?) and it smooth, then you've definitely isolated it to the transmission - 5th gear. Maybe you are already 100% sure it's 5th gear and not happening a certain speed.
If it does turn out to be a function of speed instead of gear, then you might look at U-joints, tire/wheel balance, alignment.