Personally, I wouldn't touch the hubs, unless you have a machine shop do them precisely to spec. Hub centric means just that, the wheel is centered by the hub, not the lugs. So if you screw with that hub and are even the smallest amount off, it will effect the balance of the wheel in motion.
You'll need 60degree tapered acorn lug nuts to use with the eskies, or even denali's for that matter.
I've got friends with Isuzu's, Mazda's, and Nissan's. We've had both eskies and denali's, and have had 0 problems running them bored out. Few guys had their wheels bored by a machine shop, few others have done them themselves with a set of hole saws and cutting fluid.
If you do the cut properly, use the proper equipment, take your time, use the right lug nuts and keep them torqued to spec, you'll be fine.
Need more info, or to order lug nuts, hit me up:
Sales@BlazinKuztumz.com