jeebus @ mmw
+1y
Yea, just putting filler primer over it and trying to paint it wont work to well for you.
What ive allways done in the past on the backs of sub enclosures, is sand all the edges smooth and then saturate the MDF with fiberglass resen, it will soak into the MDF and give you alittle bit more of a foundation to work with.
Ive done it with about 3 coats of the fiberglass resen, and it worked great, i was able to hit it with a DA, and spray primer and paint it.
Hope that helps
Taylor