dvsdev
+1y
My mates car stereo that he enters in sound offs has the speaker wires going in through the ports, mostly because he is running power wire for speaker wire, but it doesn't rattle enough to be noticeable, if it became an issue you could always glue them in place with hot melt glue.
I, myself don't run cups, I drill holes the size of the individual wires (4 of them) coat the wires in soap and force them through the box, once they go far enough inside I do a little sealing with liquid nails, but since it's such a tight fit on the wires its not really needed